Asked by: Jamison Goede
asked in category: General Last Updated: 3rd June, 2020

How do I reconstitute imipenem?

Reconstitute infusion bottles containing 250 mg of imipenem and 250 mg of cilastatin or 500 mg of imipenem and 500 mg of cilastatin with 100 mL of a compatible IV solution1 to provide solutions containing 2.5 or 5 mg/mL of each drug, respectively. Shake until a clear solution is obtained.

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Similarly, it is asked, how do you dilute imipenem?

Each 500mg of dose should be diluted with 100ml of compatible IV fluid, whilst for a 1gm dose use a 250ml bag. Infuse doses of 500mg over 20 minutes. Infuse doses of 500mg to 1gm over 40 to 60 minutes. If patient develops nausea during infusion, the rate of infusion may be slowed.

Also, how do you use imipenem injection? When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours. When imipenem and cilastatin is given intramuscularly, it is injected into the muscles of the buttocks or thigh once every 12 hours.

Regarding this, how do you reconstitute Primaxin?

Reconstitute PRIMAXIN in ADD-Vantage® vials with ADD-Vantage® diluent containers containing 100 mL of either 0.9% Sodium Chloride Injection or 100 mL 5% Dextrose Injection. Dosage and Administration (2.5)], maintains satisfactory potency for 4 hours at room temperature or for 24 hours under refrigeration (5°C).

Can imipenem be given orally?

Other β-Lactam Antibiotics Ertapenem, imipenem, meropenem, and doripenem are formulated as parenteral agents because they are absorbed poorly after oral ingestion. Imipenem is typically administered every 6 hours, and meropenem and doripenem are given every 8 hours.

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