Asked by: Ari Loukili
asked in category: General Last Updated: 2nd March, 2020

Why does urea cycle occur only in liver?

Organisms that cannot easily and safely remove nitrogen as ammonia convert it to a less toxic substance such as urea or uric acid via the urea cycle, which occurs mainly in the liver. Urea produced by the liver is then released into the bloodstream where it travels to the kidneys and is ultimately excreted in urine.

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In this way, what is the point of the urea cycle?

The main purpose of the urea cycle is to eliminate toxic ammonia from the body. About 10 to 20 g of ammonia is removed from the body of a healthy adult every day. A dysfunctional urea cycle would mean excess amount of ammonia in the body, which can lead to hyperammonemia and related diseases.

Secondly, is the urea cycle Endergonic? With the exception of the hydrolytic conversion of arginine to urea and ornithine by arginase, our knowledge of the enzymatic steps in the urea cycle is obscure. Since the over-all process is an endergonic one, the synthetic steps in the cycle must be coupled with energy-yielding systems.

One may also ask, where does urea synthesis occur?

In mammals, the urea synthesis takes place in the liver. The nitrogen in the amino acid becomes converted to ammonia and this is further converted by the liver into urea, which is less toxic than ammonia to the body.

Where does aspartate come from in urea cycle?

Aspartate is the source of the second amine group on urea. Recall that aspartate results from the transamination of oxaloacetate and glutamate via aspartate transaminase, which requires vitamin B. Argininosuccinate is converted into arginine via argininosuccinate lyase.

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